Our research interests include: Rheumatology, ENT, Neonates, Diabetes, General Medicine, Asthma and Childhood Diseases

Bradford Children’s Research gives babies, children, young people and their families the opportunity to be involved in research that will improve treatments and care for future generations. Together we hope to make researching the effectiveness of new and existing treatments part of routine care.

To get in touch, please call 01274 382466, or email us at Childrensresearch.Nurses@bthft.nhs.uk

Latest Research

• WHEAT – WithHolding Enteral Feeds Around Blood Transfusion https://www.npeu.ox.ac.uk/wheat 
• Interpreted conversations between doctors and parents in prenatal and neonatal care: a conversation analytic study
• BCRD– Biologics For Children With Rheumatic Diseases
• BioJUME– Biology Of Juvenile Myoclonic Epilepsy. More Details Available On http://childhoodepilepsy.org/research-studies/biojume/
• BSPAR– BSPAR Etanercept Cohort Study
• Extended Biologics– The Long-Term Safety And Efficacy Of Biologic Therapies In Children With Rheumatic Diseases.
• JDCBS– Juvenile Dermatomycosis National (UK And Ireland) Cohort Biomarker Study And Repository For Idiopathic Inflammatory Myopathies
• JSLE– UK Juvenile Systematic Lupus Erythematosus Cohort Study And Repository
• FIT-PIV – A Multi-Center, Double-Blind, Randomized, Two-Arm, Parallel-Group, Placebo Controlled Study to Assess the Efficacy and Safety of ELGN-2112 on Intestinal Malabsorption in Preterm Infants
• NeoGASTRIC – Avoiding routine gastric residual volume measurement in neonatal critical care: a multi-centre randomised controlled trial https://www.npeu.ox.ac.uk/neogastric
• COMET – Cooling in Mild Encephalopathy (COMET) trial
• GenOMICC – Genetics of Mortality in Critical Care https://genomicc.org/
• BachB – Breathing Assistance in CHildren with bronchiolitis (BACHb): a groupsequential two-stratum multicentre open-label randomised clinical trial of respiratory support in infants with acute bronchiolitis https://bachbtrial.org.uk/
• PKU GMP Nutricia – Evaluating the adherence, tolerance, acceptability and safety of new GMP-based powdered protein substitutes in PKU and TYR: a case study series
• ABBOTT Frequency of Ketosis – Frequency of Ketosis in People Living with Diabetes or Other Medical Conditions
• STAR-JIA – Steroid TreAtment tRial in JIA: A randomised trial to compare effectiveness, safety and cost-effectiveness of intravenous versus oral corticosteroid induction regimens for children and young people with juvenile idiopathic arthritis https://star-jia.org.uk/
• PeRFekT – PaEdiatric Rheumatology FramEworK for Technology enabled care: A mixed methods study to investigate current practices, experiences and perspectives (The PERFEKT study)
• IMPACT – Interventions to improve Mental health support in families with children and young people with Chronic RheumaTological conditions
• BEARS – Both EARS training package (BEARS) to maximise hearing abilities in older children and teenagers with bilateral cochlear implants https://www.bcig.org.uk/news/64/bears/

Historical Research

• SuperTRIAL – Phase 2b Trial Of BPZE1 Nasal Spray Vaccine In Healthy Children www.supertrial.co.uk
• HARMONIE Little Lungs ABC Study (Antibody Boost In Children) Study To Prevent Respiratory Infection In Infants Including Bronchiolitis, Pneumonia And Other Chest Infections Often Caused By The Respiratory Syncytial Virus https://rsvharmoniestudy.com/en-gb
• What’s The STORY – Sero-epidemiological survey of England in 2019/2020. www.whatsthestory.org.uk 
• AZTEC – The Azithromycin therapy for Chronic Lung Disease of Prematurity. www.cardiff.ac.uk/aztec
• RECOVERY – Randomised Evaluation of COVID-19 Therapy  http://www.recoverytrial.net 
• Raaceno- Reducing AsthmA AttAcks In Children Using Exhaled Nitric Oxide As A Biomarker To Inform Treatment Strategy- A Randomised Trial. More Info On https://www.raaceno.co.uk/
• NeoCLEAR – Optimising Lumbar Punctures In Newborns. For More Information, Please Visit https://www.npeu.ox.ac.uk/neoclear
• BabyOSCAR – Outcome After Selective Early Treatment For Closure Of Patent Ductus ARteriosus In Preterm Babies Https://Www.Npeu.Ox.Ac.Uk/Baby-Oscar
• Archie- The Early Use Of Antibiotics In At Risk Children With Influenza
• Boss- British Orthopaedic Surgery Surveillance Study. More details on http://www.boss.surgery/
• Elfin- –A Multi-Centre Randomised Placebo-Controlled Trial Of Prophylactic Enteral Lactoferrin Supplementation To Prevent Late-Onset Invasive Infection In Very Preterm Infants. More Details On : https://www.npeu.ox.ac.uk/ELFIN
• GSK 204959- Clinical Trial In Patients With Eosinophilic Asthma.
• Jump- Type 2 Diabetes In Childhood: Building A Platform For Interventions To Prevent The Progression To Cardiovascular Disease. More Information On : http://www.jump.bham.ac.uk/
• Magpie- Mechanisms Affecting The Gut Of Preterm Infants In Enteral Feeding Studies. More info on : www.npeu.ox.ac.uk/magpie
• MERIDIAN – Magnetic Resonance Imaging To Enhance The Diagnosis Of Foetal Developmental Brain Abnormalities In Utero (MERIDIAN). 2-3 Year Follow-Up Study
• Mini Dex- The Efficacy And Safety Of Very Low Dose Dexamethasone Used To Facilitate The Extubation Of Ventilator Dependent Preterm Babies Who Are At High Risk Of Bronchopulmonary Dysplasia. More Info On www.npeu.ox.ac.uk/minidex
• Optisurf – The effect of Surfactant dose on outcomes in preterm infants with Respiratory Distress Syndrome
• RaDar – The National Registry of Rare Kidney Diseases
• Kawasaki – Genetic determinants of Kawasaki disease for susceptibility and outcome
• OSTRICH- Oral STeroids For The Resolution Of Otitis Media With Effusion In Children Study.
• PIC Study- Petechiae In Children (PIC) Study: Defining A Clinical Decision Rule For The Management Of Fever And Non-Blanching Rashes In Children Including The Role Of Point Of Care Testing For Procalcitonin & Neisseria Meningitidis DNA.
• Planet 2- A Randomised Controlled Trial To Compare Two Different Platelet Count Thresholds For Prophylactic Platelet Transfusion To Preterm Neonates. More Info On http://www.planet-2.com/
• Prednos – Long-Term Tapering Versus Standard Prednisolone (Steroid) Therapy For The Treatment Of The Initial Episode Of Childhood Nephrotic Syndrome. More Info On : http://www.bctu.bham.ac.uk/PREDNOS
• PREVAIL– PREVenting Infection Using Antimicrobial Impregnated Long Lines. Further information can be found on http://www.prevailtrial.org.uk/
• REDEXAM- Reducing Painful Eye Examinations In Preterm Infants
• SIFT– A Multi-Centre Randomised Controlled Trial Of Two Speeds Of Daily Increment Of Milk Feeding In Very Preterm Or Very Low Birth Weight Infants. More Information Can Be Found On: www.npeu.ox.ac.uk/sift
• TEVA– A Single Visit, Open-Label Study Of The Accuracy Of Measurement Of The Maximum Inhalation Flow (MIF) Of Patients With Asthma Or COPD Using An Electronic Multi-Dose Dry Powder Inhaler (EMDPI)
• UK-Chimes – UK Childhood Meningitis And Encephalitis Cohort Study
• WAIT- Wheeze And Intermittent Treatment – A Non- Steroid Oral Medication For Wheezing.
• DOLFIN – Developmental Outcomes Of Long-Term Feed Supplementation In Neonates – The DOLFIN Randomised Controlled Trial https://www.npeu.ox.ac.uk/dolfin
• AZTEC2 (Azithromycin Therapy For Chronic Lung Disease Of Prematurity) Follow Up Studies: AZTEC@1 And AZTEC@2
• FEED-1- A Randomised Controlled Trial Of Full Milk Feeds Versus Intravenous Fluids With Gradual Feeding For Preterm Infants (30-33 Weeks Gestational Age) Https://Feed1.Ac.Uk/Home.Aspx
• NeoAMRO – Neonatal Antimicrobial Resistance And Outcome (NeoAMRO)
• FIDO –Febrile Infant Diagnostic Assessment And Outcome (FIDO) Study
• SPIROMAC – SPIROmetry To Manage Asthma In Children
• CF Start- The Cystic Fibrosis (CF) Anti-Staphylococcal Antibiotic Prophylaxis Trial (CF START); A Randomised Registry Trial To Assess The Safety And Efficacy Of Flucloxacillin As A Longterm Prophylaxis Agent For Infants With CF. More Details On  www.cfstart.org.uk
• ITP registry- UK Childhood ITP Registry
• SCIENCE – Surgery Or Cast For Injuries Of The EpicoNdyle In Children’s Elbows Https://Science.Digitrial.Co.Uk/
• CRAFFT – Children’s Radius Acute Fracture Fixation Trial Https://Crafft-Info.Digitrial.Com/
• DIvO – Can the diagnostic accuracy of newborn eye screening for congenital cataract be improved with digital imaging? The Digital Imaging versus Ophthalmoscopy (DIvO) study https://divostudy.org/
• PKU UP – An acceptability study to evaluate the compliance, gastrointestinal tolerance, palatability and metabolic control of children with phenylketonuria (PKU) when using PKU UP (a food for special medical purposes) as part of dietary management
• PIC Bone – Imaging in Paediatric Osteomyelitis (the PICBONE study): a multi-centre cohort study to understand the role of MRI and Ultrasound in the diagnosis of acute haematogenous osteomyelitis in children https://www.picbone.com/

Impact of Research

Click the links below to access the published papers from Historical Research:

• CORD – Randomised trial of cord clamping and initial stabilisation at very preterm birth. https://fn.bmj.com/content/103/1/F6
• ELFIN – A multi-centre randomised placebo-controlled trial of prophylactic Enteral Lactoferrin supplementation to prevent late-onset invasive infection in very preterm infants. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32221-9/fulltext
• MERIDIAN – Magnetic resonance imaging to enhance the diagnosis of foetal developmental brain abnormalities in utero.    https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)31723-8/fulltext
• OSTRICH- Oral STeroids for The Resolution of Otitis media with effusion in Children study. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)31490-9/fulltext
• Planet 2 – A randomised controlled trial to compare two different platelet count thresholds for prophylactic platelet transfusion to preterm neonates. https://www.nejm.org/doi/full/10.1056/NEJMoa1807320
• PREVAIL – PREVenting infection using Antimicrobial Impregnated Long lines. https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(19)30114-2/fulltext
• REDEXAM – Reducing painful eye examinations in preterm infants. https://www.nature.com/articles/pr2017179.pdf?origin=ppub